Breaking. Bird Flu in China jumps to Humans

BEIJING (Reuters) - A woman in China has died of the H10N8 strain of bird flu, the first ever reported human case of the virus, the World Health Organisation (WHO) said on Wednesday.

The 73-year-old woman died from the virus on December 6, six days after contracting the disease, the WHO said in a statement.

Bionics (the war dividend).

Great article on how Bionic technology is changing lives. We say it's due to the war dividends over the last 12 years, too bad we just didn't put the money into medical research... 

http://www.cnbc.com/id/101233869?utm_source=taboola_innovationcities

Cancer Generics $CGIX a top performing IPO

$CGIX went public in April at $10 and hits $22 almost 6mo later. Focused on DNA probes for cancer diagnostics and drug/treatment monitoring. Backing by the "Buffet" of biotech John PappaJohn, strong received  buy rating from Aegis w/ $25 target, pharma partnerships expand. (Disclosure: am early holder and long) 

Smart Phone Microscope Sees Small Virus

 Your smartphone now can see what the naked eye cannot: A single virus and bits of material less than one-thousandth of the width of a human hair.

http://scicasts.com/bio-it/1861-nanobiotechnology/6626-scientists-create-smartphone-microscope-that-can-detect-a-single-virus-nanoparticles

Sangamo's Downs Sydrome Approach

Sangamo  (SGMO) published data using their zinc finger DNA-binding protein technology to insert a gene that will essentially "silence" the extra copy of a gene that causes Downs Syndrome. The procedure provides a model for studing the basic biology of Downs syndrome, and could enable the development of drugs that can potentially rebalance the cellular processes and pathologies that are affected by the disorder.

Promising Platform for Cancer Immunotherapy


Celldex has flipped Dendreon's biological model on its head. With a goal of specifically and efficiently targeting a subset of immune cells in vivo, Celldex designed antibodies that bind to the internalization receptor (the DEC-205 receptor) on APCs, and are also tethered to the cancer antigen. The APC internalizes the antibody/antigen complex, and can then signal to T-cells to begin the assault on cancerous tissue. This method has the benefits of classical vaccines, as well as the specificity and efficiency of Dendreon's Provenge, with a fraction of the cost.

A Promising Platform for Cancer Immunotherapy - BMY, CLDX, DNDN, MRK - Foolish Blogging Network

Teen Develops Computer Algorithm to Diagnose Leukemia

Brittany Wenger isn’t your average high-school senior: She taught the computer how to diagnose leukemia.

The 18-year-old student from Sarasota, Fla. built a custom, cloud-based “artificial neural network” to find patterns in genetic expression profiles to diagnose patients with an aggressive form of cancer called mixed-lineage leukemia (MLL). Simply put, this means Wenger taught the computer how to diagnose leukemia by creating a diagnostic tool for doctors to use.

http://motherjones.tumblr.com/post/51005847861/kqedscience-teen-develops-computer-algorithm-to 


Molecular trigger for Alzheimer’s disease identified


For the first time, scientists at Cambridge’s Department of Chemistry have been able to map in detail the pathway that generates “aberrant” forms of proteins which are at the root of neurodegenerative conditions such as Alzheimer’s.

They believe the breakthrough is a vital step closer to increased capabilities for earlier diagnosis of neurological disorders such as Alzheimer’s and Parkinson’s, and opens up possibilities for a new generation of targeted drugs, as scientists say they have uncovered the earliest stages of the development of Alzheimer’s that drugs could possibly target.

The study, published today in the journal PNAS, is a milestone in the long-term research established in Cambridge by Professor Christopher Dobson and his colleagues, following the realisation by Dobson of the underlying nature of protein ‘misfolding’ and its connection with disease over 15 years ago.

Novartis produces flu vaccine in less than 5 days

Most people recall the Swine Flu epidemic of 2009. What many do not realize is that the vaccine took almost 9 months to develop and manufacture. A new study, published Wednesday in Science Translational Medicine shows that this time is being reduced drastically; flu pandemic vaccine manufacturing could begin in days, not months, potentially saving great numbers of lives. The study led by famed San Diego geneticist J. Craig Venter of the J. Craig Venter Institutealong with Rino Rappuoli of Novartis, revealed that they were able to design a vaccine in four days and four hours for a new strain of flu that had appeared in China. The new process is much faster, in part, because researchers can now use the genetic code of a virus to design its vaccine. "To my knowledge, this is the first real-world product from synthetic biology," said Venter.


New Flourescent dyes invented could significantly improve imaging

The  long life of the newly discovered  triangulenium dyes means that an image can be produced without background noise. Furthermore, the extra 90 nanoseconds opens the possibility of filming living images of the processes occurring within cells, for example when a drug attacks an illness.

http://scicasts.com/healthtech/1849-imaging-a-simulation/5963-chemistry-breakthrough-sheds-new-light-on-illness-and-health?acm=1506_837


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Human Embryonic Stem Cells Cloned

Scientists have finally succeeded in using cloning to create human embryonic stem cells, a step toward developing replacement tissue to treat diseases but one that might also hasten the day when it will be possible to create cloned babies.


http://www.nytimes.com/2013/05/16/science/scientists-use-cloning-to-create-embryonic-stem-cells.html

New Mutant Virus developed in China

NEW MUTANT VIRUS
The new mutant virus was easily transmitted between guinea pigs through respiratory droplets –
which the Chinese team said proved the deadly H5N1 virus may need but a simple genetic mutation to acquire the ability to get transmitted from human to human.

http://www.worldwidehippies.com/2013/05/05/fears-for-man-made-flu-bug-from-chinas-lab-its-not-just-china/

Bird Flu in Chna Spreads

International teams arrive and more worrisome is not finding the link between humans and poultry this time....

http://news.yahoo.com/data-bird-flu-raises-questions-human-transmission-072712645.html

Urgent Warning On New Bird Flu H7N9: Could Pose Global Threat

H7N9 avian flu virus is even more deadly than previously believed. The conclusions: H7N9 causes unusually severe respiratory infection, sepsis and brain damage, and appears to be resistant to vaccination and treatment.

http://www.forbes.com/sites/melaniehaiken/2013/04/12/new-bird-flu-danger-worse-than-believed-says-urgent-report/

New Bird Flu (again) in China

Update: China reports another death and 3 new infections from H7N9 bird flu, bringing death toll to 14 and number of infections to 63 - @Reuters

Rock Stars of Innovation

We're attending the "Rock Stars of Innovation" themed meeting at the Hard Rock Hotel in San Diego. Looking for that next Edison...or idea.

"Functional cure" of HIV Reported

A study of 14 patients who were treated with antiviral HIV medications within weeks of infection now have now have no disease activities years after stopping medication. The research comes weeks after news spread that a Mississippi baby who was born with HIV and received immediate treatment was now disease-free at two and a half years

old.http://m.cbsnews.com/storysynopsis.rbml?pageType=health&url=http://www.cbsnews.com/8301-204_162-57574611/functional-cure-of-hiv-reported-in-14-patients-french-scientists-say/&catid=57574611






Baby with HiV cured!

The child's story is the first account of an infant achieving a so-called functional cure, a rare event in which a person achieves remission without the need for drugs and standard blood tests show no signs that the virus is making copies of itself.

http://mobile.reuters.com/article/idUSBRE9220GB20130304?irpc=932

Progress in the effort to map all the proteins made by human chromosomes.

Human Proteome Project (C-HPP), a 10-year initiative to map all the proteins produced by genes on human chromosomes. The C-HPP was launched last year, and organizers of the effort envision a close to their activities occurring in September of 2022. The current issue of the Journal of Proteome Research is devoted entirely updating the progress of the international teams of scientists involved with the C-HPP.


http://www.the-scientist.com/?articles.view/articleNo/34117/title/Human-Proteome-Project-Update/



My genetic code on my iPhone?

A guy walks into a bar. Says hey baby check out my genome? Or checks in at CVS to ensure he us right for prescription

http://m.ocregister.com/articles/dna-383823-genome-tsudik.html

Human Genome by the "numbers"

Interesting article about Human Genome "numbers"

http://ngs-brescia.blogspot.com/2013/01/my-essentials-about-human-genome-numbers.html?m=1

Search of DNA Sequences Reveals Full Identities Uh Oh


Dr. Erlich began with one man from the database. He got the Y chromosome’s short tandem repeats and then went to genealogy databases and searched for men with those same repeats. He got surnames of the paternal and maternal grandfather. Then he did a Google search for those people and found an obituary. That gave him the family tree.
“Now I knew the whole family,” Dr. Erlich said. And it was so simple, so fast.



Search of DNA Sequences Reveals Full Identities - NYTimes.com

FLU season worst in Decades

The stock holders of Walgreen's and CVS thank all that skipped getting a safe and effective vaccination to protect not only yourself but others from this years rather extreme virulent flu.

http://m.cnbc.com//id/100363819

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