Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology

In a paper published in the July 24, 2009 issue of Science, researchers describe the novel application of ZFNs to generate rats with permanent, heritable gene mutations, paving the way for the development of novel genetically modified animal models of human disease. ZFN technology will make the generation of such animals faster and will create new opportunities in species other than mice.

"Until now, rat geneticists lacked a viable technique for 'knocking out,' or mutating, specific genes to understand their function," said Howard Jacob, Ph.D. Director of the Human and Molecular Genetics Center at the Medical College of Wisconsin. "This study demonstrates that ZFN technology bypasses the current need to conduct cumbersome experiments involving nuclear transfer (cloning) or embryonic stem cells and allows rapid creation of new animal models."


George said...

Congratulations to all researchers involved in the creation of the first targeted knockout rats using ZNF Technology.

For access to the database of random knockout rat models, please visit the Knock Out Rat Consortium website at and click the orange “Rat Models” button. Knockout Rats on this database are available commercially through Transposagen –

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