Intracellular Observation Of RNA Metabolism Will Help Identify Disease-associated RNAs

Now we have a workable system to understand all aspects of RNA metabolism in a cell," say Eberwine. "For the first time, we can study how manipulation of cellular physiology, such as administering a drug, changes RNA-binding protein and RNA interactions. This technology allows us to see that in real time in real cells."

Intracellular Observation Of RNA Metabolism Will Help Identify Disease-associated RNAs

Fred Siegman, a friend we will miss

On December 30th Fred Siegman a friend and colleague of many of us who frequent this blog passed away. Fred possessed boundless energy and creativity so work or play was rarely dull when he was around. He was an extremely talented actor and musician and possessed strong business acumen. But of all of his talents, qualities, and skills the ones I value most were his honesty and integrity. I never knew Fred to compromise his values, he stayed the course. He was a friend you could always count on.

Fred you will be missed.


BioBOOM Op/Ed: Dr. Siegman, yes this Ph.D. never throwing his degree around was a leader and pioneer in the Biotech tool industry. He was involved with numerous start ups and handled alot of the day to day dirty work for companies to be successful in the early stages. In the long run he brought untold millions of dollars of value with his small day to day efforts for the industry we know today. Most recently we at BioBOOM were discussing new ideas such as biotech "podcasting" with Fred as the host. God knows how entertaining that would have been. But heaven's gain is our loss. Enjoy Fred. We miss you but know that you made your mark and were called to a higher effort much earlier then we anticipated.

First Bird Flu Death Confirmed in Iraq

A 15-year-old Kurdish girl who died this month had the deadly H5N1 strain, Iraq and U.N. health officials said. The prospect of a bird flu outbreak in Iraq is alarming because the country is gripped by armed insurgency and lacks the resources of other governments in the region.

First Bird Flu Death Confirmed in Iraq - Yahoo! News

Germ Sensors

Bird flu and bioterrorism threats are creating healthy opportunities for outfits that sniff out lethal bugs.

Germ Sensors -

Bird Flu Gene Analysis Finds New Clue

St. Jude researchers reported in the journal Science that they have completed the first large genetic analysis of more than 300 of these bird flu viruses. They identified 2,196 bird flu genes and 160 complete genomes, doubling the amount of genetic information available for scientists to study how these viruses evolve and spread over time. Simply having that new trove of gene information — posted in a public genetic database so that any scientist can mine it — in itself is a huge step, said Dr. Maria Giovanni of the National Institutes of Health which has launched a major project to map influenza genomes and helped to fund the St. Jude's work. So far, most of the complete influenza genomes available are from human viruses.

Bird Flu Gene Analysis Finds New Clue - Yahoo! News

BioBOOM Op/Ed: Ok folks here is where our investment in the genome project could pay off early. Lots of tool have been developed to speed up sequencing and similar to the off shoot of engineering from the investment in the space program during the 60's we now see similar affects this century from the genome project and hopefully, right when we might need it.

Paging Dr. Google

Google also has proved very useful to physicians and clinical researchers. As one fellow told his professor during grand rounds in a New York hospital, "I entered the salient features into Google, and [the diagnosis] popped right up" (Giustini, BMJ, 12/24/05). Google operates both the general search engine, as well as Google Scholar. Google Scholar is not linked to the general search engine but instead uses an algorithm to targeted so-called scholarly material. Google also offers an image search, which is useful to clinicians who can search clinical cases and then find corresponding images online.

Whether or not we'll be able to Google our genes by 2010, Google surely will be a top reference source for consumers, clinicians and researchers. The company is moving at breakneck speed for growth in all areas, hiring the best and brightest techies around the world. Clearly, health care is among Google's most important vertical markets.

Paging Dr. Google - iHealthBeat - Daily News Digest on Health Care Information Technology

BioBOOM Op/Ed: Great article and it should be noted another reason good marketing in biotech needs to deal with this access point.

ABC News: Poll: Most Find Medicare Program Puzzling

"I pretty much completed a master's degree in psychology and I can't understand it," said Raymond Lloyd, a Republican-leaning retiree from Silt, Colo. "For the elderly who don't have their full faculties and the poor people who are not well educated, God help 'em."

ABC News: Poll: Most Find Medicare Program Puzzling

Yogurt may help stop HIV infections, report says

Lactococcus lactis, a bacterium used to produce cheese and yogurt, was altered genetically by the scientists to generate cyanovirin, a drug that has been used to stop HIV infection in the cells of monkeys and humans, said on its Web site.

Yogurt may help stop HIV infections, report says

GOt MiLk?

NIH Halts International AIDS Study

A major international study of a drug-conserving
AIDS' therapy has been halted because patients trying the on-again, off-again strategy got sicker than those who never took a break from the high-powered drugs, U.S. researchers announced Wednesday.

NIH Halts International AIDS Study - Yahoo! News

DeCode Genetics Claims Discovery of Major Genetic Risk Factor for Type 2 Diabetes

In a scientific paper published today a team of scientists from deCODE genetics and colleagues report the discovery of a variant in a gene on chromosome 10 that represents the most significant genetic risk factor for type 2 diabetes (T2D) found to date. More than one third of individuals in the populations studied carry one copy of the at-risk variant and are at an approximately 45% increased risk of the disease compared to controls; 7% carry two copies and are at a 141% greater risk. The original finding was made in Iceland and was subsequently confirmed in studies in Denmark and the United States.

Major health emergency' in Calif. from drug plan

Problems with the federal government's new Medicare prescription drug plan are creating a health crisis in California, Sen. Dianne Feinstein said Friday, a day after the state announced emergency drug coverage for California's seniors because of the problems. The problems appear to stem from the fact that 6 million elderly, low-income and disabled people - including 1 million Californians - were automatically switched into the new drug program Jan. 1. These people previously had been covered by the Medicaid state-federal health care program for the poor, called Medi-Cal in California.mThe system was apparently not equipped to handle the influx.

AP Wire 01/13/2006 Feinstein: 'Major health emergency' in Calif. from drug plan

Taiwan breeds transgenic, fluorescent, green pig

"There are partially fluorescent green pigs elsewhere, but ours are the only ones in the world that are green from inside out. Even their hearts and internal organs are green," Wu said on Thursday.

Science'>">Science News Article Posted by Picasa
Some Interesting slides from JP Morgan Conference

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JPMorgan Healthcare Conference - connect here for Free!

You can listen to selected webcasts from the JPMorgan 24th Annual Healthcare Conference. JPMorgan’s premier conference on the healthcare industry features more than 260 public and private companies over four days of simultaneous sessions in San Francisco, CA. In addition, the conference hosts topical panel discussions featuring leading industry experts. And the cool think is you register for free and can listen to alot of them. We plan to post some slides we find interesting. So stay tuned.

JPMorgan Healthcare Conference - Sign In

Amylin designing trial of sustained diabetes drug

San Diego-based Amylin announced in August positive preliminary results from a 15-week study of the drug, a once-a-week injection called Exenatide LAR

Latest News and Financial Information |

If you wonder why this is important, read this:

Living at an Epicenter of Diabetes, Defiance and Despair - New York Times

Biotech investors swarm into S.F. after encouraging year / JPMorgan meeting promising venue to make sweet deals

Biotech's annual kickoff conference, which starts today at the Westin St. Francis Hotel in San Francisco, is like a slightly delayed New Year's Eve party, with revelers celebrating the past year's triumphs, resolving to do better in the future while cruising for new relationships. In the Bay Area, the noteworthy deals in play include Amgen's $2.2 billion purchase offer for the Fremont biotech company Abgenix, and Novartis' pending $5.1 billion offer for the pioneering Emeryville biotech company Chiron Corp.

Biotech investors swarm into S.F. after encouraging year / JPMorgan meeting promising venue to make sweet deals

U.S. Farmers to Begin Testing Chickens for Flu

The National Chicken Council said that poultry-processing companies that control about 90 percent of the nation's chicken production had joined the program. By Jan. 16, they are to start testing about 1.6 million birds a year, a council spokesman said.Under the program, chicken farmers, most of whom raise flocks under contract with major processors like Tyson Foods or Pilgrim's Pride, will take swabs or beak samples from 11 chickens in each healthy flock. Any suspicious results found in local laboratories will be sent on to a U.S.D.A. laboratory in Ames, Iowa, for confirmation.

U.S. Farmers to Begin Testing Chickens for Flu - New York Times

Hospitals' profit margin hits 6-year high in 2004

The hospital industry is in the midst of its biggest construction boom in 50 years, spending nearly $100 billion in inflation-adjusted dollars in the past five years for new and expanded facilities nationwide, often in rapidly growing suburban areas. That spending comes as conditions have been good for both borrowing and spending. Hospitals reported an average 5.2% profit margin in 2004, the last full year of data available from the American Hospital Association.

Colon cancer test is promising

Epigenomics in Seattle has the potential to help doctors spot colorectal cancer sooner -- before symptoms appear -- and when relatively tolerable treatments offer an excellent chance for survival.
The molecular diagnostics company said this past week that studies on more than 2,000 blood samples showed its test can detect an altered gene associated with colorectal cancer from 50 percent to 65 percent of the time, in both early and advanced cancer. The current standard of practise - the fecal blood test, misses many cancers. Its sensitivity is about 20 or 30 percent -- about half the sensitivity Epigenomics reported -- when used as part of an annual program

Colon cancer test is promising |

BioBOOM Op/Ed: This is good news, especially to those of us as we reached 40 had to do the in-home stool test collecton kit made by Beckman. That has to be the worst designed process we have ever seen. We even wrote the CEO of Beckman Coulter to complain but did we get a response? Nooooooo.... maybe another example of out of touch management in diagnostics. Glad to see there is a new approach and one that is using MDx technology.

Biotech research has freer hand in Asia

Biotechnology research has taken off in Asia. In the West, religious and moral concerns are hampering research like never before. Scientists face attack from politicians, the media, pressure groups and religious bodies. But in Asia, where dissent tends to be muzzled, there are fewer obstacles.

Biotech research has freer hand in Asia - Business - Business -

From Fierce Biotech

Pharmacogenomics Makes an Important Regulatory Debut

Revolutions often start small, and this one is embarking at the molecular level. Last year marked the first fledgling effort by the FDA to start gathering voluntarily submitted genomic data on new drugs. But as the agency makes clear, there will be a growing focus on finding patient subsets that benefit from a specific drug targeted to their condition. New genomic information is already being added to the labels of a handful of pioneering drugs. In the near future, that number is likely to grow exponentially--a trend no one with drugs in the pipeline can ignore.

The advantage here is that drug developers will be able to tailor drugs for specific groups, raising the likelihood of approval and making a solid case for inclusion on payers' drug formularies. The downside is that as drugs become more targeted, less waste will inevitably translate into lower revenue.

Welcome to the revolution.....

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