Scientists identify novel gene driving the growth and survival of melanoma cells

Scientists at Dana-Farber Cancer Institute have discovered a genetic abnormality in the cells of some advanced melanoma patients that worsens their chances of survival, but also might be a target of future drug attack against the dangerous skin cancer. Abnormal amplification of the MITF gene was found to be associated with other genetic changes as well. They included mutations in a gene, BRAF, previously found in melanoma cells, and silencing of p16, a “tumor-suppressor” gene that normally keeps cells from dividing too rapidly and causing cancer.

Scientists identify novel gene driving the growth and survival of melanoma cells

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