Alnylam Grants Ambion License to Fundamental RNAi Patents for Applications in the Research Products Market

Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY) a leading RNAi therapeutics company, announced today that it has granted Ambion, Inc. a non-exclusive license to provide research products and services in RNA interference (RNAi) under the Kreutzer-Limmer patent family owned by Alnylam. This patent family covers short interfering RNAs (siRNAs) and their use to mediate RNAi in mammalian cells. On May 11, 2005, Alnylam announced that the European Patent Office granted a new patent that significantly extended the claims of the original Kreutzer-Limmer patent. These broad new claims cover compositions, uses, and methods for siRNAs, the molecules that mediate RNAi.

About RNA Interference (RNAi)

RNA interference, or RNAi, is a naturally occurring mechanism within cells for selectively silencing and regulating specific genes. Since many diseases are caused by the inappropriate activity of specific genes, the ability to silence and regulate such genes selectively through RNAi could provide a means to treat a wide range of human diseases. The discovery of RNAi has been heralded by many as a major breakthrough, and the journal Science named RNAi the top scientific achievement of 2002, as well as one of the top 10 scientific advances of 2003.


Alnylam Grants Ambion License to Fundamental RNAi Patents for Applications in the Research Products Market

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