Gene Variants Predict Bleeding after Heart Surgery

Duke University Medical Center researchers have found that the presence of specific variants of genes that control clotting and the contractility, or "tone," of blood vessels can double the ability of physicians to predict those heart surgery patients at greatest risk of bleeding after surgery. While larger studies are needed to investigate the genetic associations we have uncovered, if our observations are confirmed, genetic screening could become an important part of our pre-operative evaluation of heart surgery patients," said Duke anesthesiologist Ian Welsby, M.D., lead author of a study to be published in the June edition of the Journal of Thrombosis and Haemostasis but appearing early on-line.

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