Compound Fights Gleevec-Resistant Leukemia

The study, published in the February issue of Cancer Cell, found that a compound called AMN107 effectively blocked proliferation of Bcr-Ab1-dependent cells taken from CML patients. Bcr-Ab1 is a protein that's abnormally active in many CML patients. AMN107 proved to be a more potent inhibitor of Bcr-Ab1 than Gleevec (imatinib), inhibiting the growth of cells expressing numerous Bcr-Ab1 mutations resistant to Gleevec.


Yahoo! News - Compound Fights Gleevec-Resistant Leukemia

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